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Leading pharmaceutical innovation: trends and drivers for growth in the pharmaceutical industry

Author: Gassmann, Oliver ; Reepmeyer, Gerrit ; Von Zedtwitz, MaximilianPublisher: Springer, 2004.Language: EnglishDescription: 178 p. : Graphs/Ill. ; 24 cm.ISBN: 3540407170Type of document: BookBibliography/Index: Includes bibliographical references and index and glossary
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Item type Current location Collection Call number Status Date due Barcode Item holds
Book Asia Campus
Main Collection
Print HC2000 .P4 G37 2004
(Browse shelf)
900097951
Available 900097951
Total holds: 0

Includes bibliographical references and index and glossary

Digitized

Leading Pharmaceutical Innovation Trends and Drivers for Growth in the Pharmaceutical Industry Contents Preface.................................................................................................v I. Innovation as a Key Success Factor in the Pharmaceutical Industry..............................................................................................1 The Productivity Paradox................................................................... 1 The Blockbuster Imperative................................................................5 Strategies for Growth..........................................................................10 Do You Want to Be in This Industry?................................................ 13 Bargaining Power of Suppliers........................................................... 15 Bargaining Power of Buyers...............................................................15 Risk of Entry from Potential Competitors.......................................... 16 Threat of Substitute Products..............................................................17 Regulative Forces................................................................................17 Rivalry among Established Companies.............................................. 18 Differentiation via Clinical Profiles.................................................... 19 Entering the Market Quickly.............................................................. 20 Conclusions......................................................................................... 21 II. Pharmaceutical Innovation: The Case of Switzerland...................... 23 Largest Economic Value-Added of GDP in Switzerland................... 23 Stable Market Growth.........................................................................25 Sound Productivity and Employment................................................. 30 Strong Support by Industry Associations............................................31 Highly Global Orientation.................................................................. 33 Complex Industry and Product Classification.................................... 34 Fragmented Market Structure............................................................. 39 Conjoined Financing Systems.............................................................43 Strict New Drug Registration..............................................................44 Accurate Price Regulation.................................................................. 50 x Contents III. The Science and Technology Challenge: How to Find New Drugs............................................................................................... 53 Rise of the Biotechnology Industry: Boosting Innovation.............. 53 High-Throughput Screening: Fail Earlier, Succeed Sooner............ 58 Combinatorial Chemistry: Cut Experimental Cycle Times.............59 Bioinformatics: More than 100 Gigabyte of Data per Day............. 60 Proteomics: Profiting from the Human Genome Project.................62 Genomics: Towards Individualization and Mass Customization.... 63 Pharmacogenomics: Create Tailor-made Drugs..............................66 Molecular Design: From Experimenting to Analytic Design..........67 Conclusions......................................................................................68 IV. The Pipeline Management Challenge: How to Shape the Innovation-Flow............................................................................. 71 The Importance of Pipeline Management........................................71 The Complexity of Drug Discovery................................................ 75 The Different Phases of the RandD Process...................................... 79 The RandD Process at Hoffmann-La Roche...................................... 82 Conclusions ................................................................................ 85 V. The Outsourcing and Internationalization Challenge: How to Harness Outside Innovation..........................................................87 Impact of Outsourcing on the Pharmaceutical Value Chain........... 87 Successful Commercialization of a Breakthrough Technology...... 91 Trends and Drivers of Internationalization...................................... 97 RandD Internationalization of Swiss Pharmaceutical Companies... 102 Locations of Pharmaceutical RandD Abroad.....................................106 Three Principal Problems of International RandD............................. 110 Conclusions...................................................................................... 114 VI. Management Answers to Pharmaceutical RandD Challenges......... 117 Managing the Research-to-Development Handover....................... 117 Managing Human Resources........................................................... 119 Managing Projects and the Portfolio................................................ 121 Managing Outsourcing Activities.................................................... 124 Managing Intellectual Property Rights............................................ 127 Managing RandD Strategy at Schering.............................................. 131 Managing Virtual Project Management Pools at Roche..................133 Managing Uncertainty at Roche...................................................... 135 Contents xi Managing Know-how Transfer at Kao...........................................136 Conclusions.................................................................................... 137 VII. Future Directions and Trends....................................................... 139 VIII. Appendices..................................................................................... 143 Case: RandD Management at Novartis............................................. 143 Case: RandD Management at Roche................................................ 151 Bibliography................................................................................... 159 Index............................................................................................... 165 Glossary.......................................................................................... 171 Authors........................................................................................... 177

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